As for Curse of the Unknown, remember that you start with 3 HP as Isaac and simply try to keep track of any hits or heals you get as you proceed through the floor. Devil Deals can be potentially more dangerous than normal unless you are confident in your HP status. Starting Items - Number One, E Coli, Butt Bombs, Flush, Petrified PoopĪ reasonably easy challenge, High Brow will see you make your way to and defeat Mom using items themed around toilet humor.Īs you only have to reach Mom, the challenge shouldn't be too difficult.While the items may not seem too great, they can provide some useful combinations. E Coli and Flush both work well together with Petrified Poop. E Coli and Flush both turn all regular enemies into poop which while holding Petrified Poop have a higher chance of dropping coins when broken open. Number One gives you a very good fire rate but limits your range quite significantly so one aim will be to pick up any boss items that extend range (Lazy Worm and Whip Worm are also great trinkets that extend your range with good effect) and pills can be a great resource if Range Up pills are in your run's rotation. Items that give any sort of brief invincibility like the Chariot card synergize well with E Coli allowing you to turn enemies into poop without worrying about the contact damage. Starting Items - Tiny Planet, Soy Milk, Iron Bar, Small Rock.įlush is great for the tougher rooms and also have the ability to kill Dingle & Dangle instantly.This is one of the tougher challenges but thankfully you only have to defeat Mom to clear it. Tiny Planet makes your tears orbit around your character instead of being shot in a specific direction which can make targeting specific enemies a bit tougher than usual. Soy Milk gives you crazy fire rate but your damage will be extremely low so many more hits will be needed to kill enemies (though you get Small Rock which makes it a little less terrible). Iron Bar can be a bit of a double-edged sword as while it does stun enemies for you, it also makes their movements more erratic making them harder to predict and avoid. Good items for this run are Spoon Bender for homing shots (making aim less of an issue). Brimstone is a massive help and can more or less win you the challenge on its own as it gives you a large ring of brimstone laser around your character. Starting Items - Razor Blade, Pentagram, Dead Bird, Whore of Babylon, Sacrificial Dagger, Dark Matter.Īnother easier way to get through the challenge is to take advantage of a 1 or 6 pip dice room which will re-roll all of your items and can usually just turn it into a regular run.Unlocked By - Defeat Mom's Heart 11 timesĪ challenge that is a bit easier than it sounds as it is practically just a regular Eve run.Starting with the Razor Blade item allows you to get into the Whore of Babylon state right away and allows you to keep it up should you accidentally pick up red hearts. When you also have soul or demon hearts as the Razor Blade will only deal red heart damage as long as you have red heart health. Sacrificial Dagger can be a great item if used properly as it can block enemy tears as well as deal heavy damage. Additionally when paired with an item that provides invincibility, it can easily clear a room with little effort.
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